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GCSE Biology practice quiz

Two sets of 12 multiple-choice questions on core GCSE Biology ideas. Choose one answer for each, press Check my answers, and read the explanation for every question. Nothing is saved or sent anywhere.

These are general practice questions and are not taken from any exam board paper. Wording on your own papers may differ.

Set 1: cells, digestion, infection, energy and inheritance

Question 1 of 12
Which part of an animal cell controls what enters and leaves it?
Question 2 of 12
Which substance makes up the cell wall of a plant cell?
Question 3 of 12
Why does an enzyme stop working at a very high temperature?
Question 4 of 12
A food sample turns blue-black when iodine solution is added. What does this show?
Question 5 of 12
Which feature of the small intestine helps absorb digested food quickly?
Question 6 of 12
How does a vaccine help to protect against a disease?
Question 7 of 12
Which word equation summarises photosynthesis?
Question 8 of 12
Which substance builds up in muscles during anaerobic respiration in humans?
Question 9 of 12
Which hormone lowers blood glucose concentration?
Question 10 of 12
What is an allele?
Question 11 of 12
Two parents are both Bb, where B is dominant. What is the chance that a child is bb?
Question 12 of 12
What does mitosis produce?

Set 2: transport, control, evolution, ecology and practical skills

Question 1 of 12
What is osmosis?
Question 2 of 12
Which blood vessel carries blood away from the heart at high pressure?
Question 3 of 12
What does xylem carry in a plant?
Question 4 of 12
Which change would make a plant lose water by transpiration faster?
Question 5 of 12
Which type of pathogen is not treated by antibiotics?
Question 6 of 12
Photosynthesis stays at the same rate when light intensity is increased. What is the most likely explanation?
Question 7 of 12
What does negative feedback do?
Question 8 of 12
Which statement best describes natural selection?
Question 9 of 12
In the food chain grass → rabbit → fox, which organism is the producer?
Question 10 of 12
Which conditions usually make decay happen fastest?
Question 11 of 12
Why use random coordinates to place quadrats in a field?
Question 12 of 12
In an investigation, what is the independent variable?

Next steps

Look up unfamiliar words in the Biology glossary, then follow the plan in the revision guide. Put missed questions into the flashcards tool.

Part of the GCSE Biology revision set: the revision guide and glossary of key terms.

Sources

Last checked: 28 October 2026

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